I lead a research group at Zhejiang University studying how cells regulate gene expression after transcription. We combine high-throughput sequencing, RNA biochemistry, functional genomics, and machine learning to understand how mRNA poly(A) tails and translation are controlled in oocytes, early embryos, and human disease.
I’m an Assistant Professor and ZJU100 Investigator at Zhejiang University. Before starting my lab, I elucidated the structural basis of the pre-mRNA 3′-end processing machinery, defined the molecular mechanism underlying the coupling between poly(A)-tail length and translational efficiency, uncovered the dynamic regulation of mRNA poly(A)-tail length during vertebrate early development, and developed PAL-AI, a neural network model for predicting changes in poly(A)-tail length. My lab now asks three questions:
We are looking for motivated students and postdocs — visit the lab website or email me.
Outside my work, I like building things, exploring nature, making videos, playing games, and watching movies.
I worked on multiple projects about post-transcriptional gene regulation.
I carried out structural and biochemical studies on transcription-coupled mRNA 3’-end processing.
